Increased Medial Orbitofrontal [18 F]fluorodopa Uptake in Parkinsonian Impulse Control Disorders
Identifieur interne : 001088 ( Main/Exploration ); précédent : 001087; suivant : 001089Increased Medial Orbitofrontal [18 F]fluorodopa Uptake in Parkinsonian Impulse Control Disorders
Auteurs : Juho Joutsa [Finlande] ; Kirsti Martikainen [Finlande] ; Solja Niemel [Finlande] ; Jarkko Johansson [Finlande] ; Sarita Forsback [Finlande] ; Juha O. Rinne [Finlande] ; Valtteri Kaasinen [Finlande]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
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Abstract
Background: Impulse control disorders (ICDs) occur frequently in PD patients. Methods: To investigate the possible involvement of the mesostriatal and mesolimbic monoaminergic function in ICDs associated with PD, we examined patients with (n = 10) and without (n = 10) ICDs using the brain [18F]fluorodopa PET. Results: Patients with ICDs (e.g., pathological gambling, hypersexuality, and compulsive eating) showed up to 35% higher [18F]fluorodopa uptake in the medial orbitofrontal cortex, compared to control patients, but no differences in the striatum. The results remained significant also after excluding subjects with comorbid psychiatric disorders. Conclusions: Increased monoaminergic activity in the medial orbitofrontal cortex might be associated with increased sensitivity for ICDs under dopamine-replacement therapy in PD.
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aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Turku PET Centre, Turku University Hospital, Abo Akademi University and University of Turku</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Turku Doctoral Program of Biomedical Sciences</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Martikainen, Kirsti" sort="Martikainen, Kirsti" uniqKey="Martikainen K" first="Kirsti" last="Martikainen">Kirsti Martikainen</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>The Finnish Parkinson Association and Foundation</s1><s2>Turku</s2><s3>FIN</s3><sZ>2 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Niemel, Solja" sort="Niemel, Solja" uniqKey="Niemel S" first="Solja" last="Niemel">Solja Niemel</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Psychiatry, University of Turku</s1><s3>FIN</s3><sZ>3 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Johansson, Jarkko" sort="Johansson, Jarkko" uniqKey="Johansson J" first="Jarkko" last="Johansson">Jarkko Johansson</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Turku PET Centre, Turku University Hospital, Abo Akademi University and University of Turku</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Forsback, Sarita" sort="Forsback, Sarita" uniqKey="Forsback S" first="Sarita" last="Forsback">Sarita Forsback</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Turku PET Centre, Turku University Hospital, Abo Akademi University and University of Turku</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Turku PET Centre, Turku University Hospital, Abo Akademi University and University of Turku</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Kaasinen, Valtteri" sort="Kaasinen, Valtteri" uniqKey="Kaasinen V" first="Valtteri" last="Kaasinen">Valtteri Kaasinen</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Turku PET Centre, Turku University Hospital, Abo Akademi University and University of Turku</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emission tomography</term><term>Impulse control disorder</term><term>Nervous system diseases</term><term>Orbitofrontal cortex</term><term>Parkinson disease</term><term>Positron emission tomography</term><term>Uptake</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Trouble du contrôle des impulsions</term><term>Pathologie du système nerveux</term><term>Captation</term><term>Tomoscintigraphie</term><term>Tomographie par émission de positons</term><term>Cortex orbitofrontal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Impulse control disorders (ICDs) occur frequently in PD patients. Methods: To investigate the possible involvement of the mesostriatal and mesolimbic monoaminergic function in ICDs associated with PD, we examined patients with (n = 10) and without (n = 10) ICDs using the brain [<sup>18</sup>F]fluorodopa PET. Results: Patients with ICDs (e.g., pathological gambling, hypersexuality, and compulsive eating) showed up to 35% higher [<sup>18</sup>F]fluorodopa uptake in the medial orbitofrontal cortex, compared to control patients, but no differences in the striatum. The results remained significant also after excluding subjects with comorbid psychiatric disorders. Conclusions: Increased monoaminergic activity in the medial orbitofrontal cortex might be associated with increased sensitivity for ICDs under dopamine-replacement therapy in PD.</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Finlande occidentale</li></region><settlement><li>Turku</li></settlement><orgName><li>Université de Turku</li></orgName></list><tree><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Joutsa, Juho" sort="Joutsa, Juho" uniqKey="Joutsa J" first="Juho" last="Joutsa">Juho Joutsa</name></region><name sortKey="Forsback, Sarita" sort="Forsback, Sarita" uniqKey="Forsback S" first="Sarita" last="Forsback">Sarita Forsback</name><name sortKey="Johansson, Jarkko" sort="Johansson, Jarkko" uniqKey="Johansson J" first="Jarkko" last="Johansson">Jarkko Johansson</name><name sortKey="Joutsa, Juho" sort="Joutsa, Juho" uniqKey="Joutsa J" first="Juho" last="Joutsa">Juho Joutsa</name><name sortKey="Joutsa, Juho" sort="Joutsa, Juho" uniqKey="Joutsa J" first="Juho" last="Joutsa">Juho Joutsa</name><name sortKey="Kaasinen, Valtteri" sort="Kaasinen, Valtteri" uniqKey="Kaasinen V" first="Valtteri" last="Kaasinen">Valtteri Kaasinen</name><name sortKey="Kaasinen, Valtteri" sort="Kaasinen, Valtteri" uniqKey="Kaasinen V" first="Valtteri" last="Kaasinen">Valtteri Kaasinen</name><name sortKey="Martikainen, Kirsti" sort="Martikainen, Kirsti" uniqKey="Martikainen K" first="Kirsti" last="Martikainen">Kirsti Martikainen</name><name sortKey="Niemel, Solja" sort="Niemel, Solja" uniqKey="Niemel S" first="Solja" last="Niemel">Solja Niemel</name><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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